Method for inhibiting activation of the human A3 adenosine receptor to treat asthma

Method for inhibiting activation of the human A3 adenosine receptor to treat asthma

• Marlene A. Jacobson
  
• Richard Arthur Norton (1958- ) on August 8, 1996
• Prasun K. Chakravarty

Abstract:
The invention is a method for inhibiting activation of the human A3 adenosine receptor with adenosine, by treating the receptor a compound of the formula [structure] to treat asthma.

• Patent number: 5780481
• Filing date: Aug 8, 1996
• Issue date: Jul 14, 1998
• Inventors: Marlene A. Jacobson, Richard Norton, Prasun K. Chakravarty
• Assignee: Merck & Co., Inc.

• U.S. Classification: 514/293; 514/294; 514/359; 514/461
• International Classification: A61K 3144; A61K 3141; A61K 3134

2,6-diaryl pyridazinones with immunosuppressant activity

2,6-diaryl pyridazinones with immunosuppressant activity
Richard Arthur Norton (1958- ) on February 23, 1995

Abstract:
A class of 2,6-diarylpyridazinones of general structural formula I have been identified that exhibit exhibit immunosuppressant activity with human T-lymphocytes, and are useful as an immunosuppressants. [Structure] or a pharmaceutically acceptable salt, hydrate or crystal form thereof, wherein:

• Patent number: 5506228
• Filing date: Feb 23, 1995
• Issue date: Apr 9, 1996
• Inventors: Richard Norton, Mohammed K. A. Ibraham
• Assignee: Merck & Co., Inc.

• U.S. Classification: 514/247; 544/240
• International Classification: A61K 3150